Open AccessEfficient and Facile Synthesis of Benzimidazole Induced Schiff Bases and their Potent Antibacterial Activity and Computational Study
Author(s) -
Shailesh S. Gurav,
Krishnakant T. Waghmode,
Bandoba T. Nikam
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23163
Subject(s) - benzimidazole , chemistry , antibacterial activity , schiff base , bioavailability , docking (animal) , combinatorial chemistry , in vitro , penetration (warfare) , proton nmr , carbon 13 nmr , nuclear chemistry , stereochemistry , bacteria , biochemistry , pharmacology , organic chemistry , medicine , genetics , nursing , operations research , engineering , biology
Synthesized benzimidazole induced Schiff base analogues were characterized by mass, 13C NMR, 1HNMR and UV-visible spectroscopy. To get more information about binding mechanism, moleculardocking studies were carried out and the obtained results concluded that the compounds could effectivelybind with receptor. in vitro Antibacterial screening was carried out against four strains (S. aureus, B.subtilis, P. aeruginosa and E. coli) and exhibited good antibacterial activity. The gastrointestinalabsorption (HIA) and brain penetration (BBB) was evaluated by The BOILED-Egg model, whichshowed that two compounds anticipated being effectively effluated by the P-glycoprotein from centralnervous system after penetration and can accounts for brain access and passive gastrointestinalabsorption. Computational screening showed 0.55 bioavailability score for all synthesized compounds.