Open AccessDesign, Synthesis and Biological Activities of Dihydroaurones
Author(s) -
Somepalli Venkateswarlu,
Gandrotu Narasimha Murty,
Megha Satyanarayana,
Vidavalur Siddaiah
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23139
Subject(s) - chemistry , gallic acid , tyrosinase , antioxidant , cinnamates , enzyme , organic chemistry , biochemistry
To widen aurones applicability in achromatic food and cosmetic applications, a series of dihydroauroneswere designed to mimic natural aurones as well as synthetic aurones. Dihydroaurones have beensynthesized from the corresponding aurones by hydrogenation. These dihydroaurones and theircorresponding aurones were screened for antioxidant, anti-inflammatory and tyrosinase enzymeinhibitory activity. Synthesized dihydroaurones (3b-f) displayed superior antioxidant activity insuperoxide free radical scavenging assay than the standard gallic acid. Dihydroaurones (3b-f) alsoexhibited significant tyrosinase enzyme inhibitory activity and two dihydroaurones (3h, 3j) showedpromising 5-lipoxygenase inhibitory activity.