z-logo
open-access-imgOpen Access
Anti-inflammatory and Antioxidant Activities of Teucrium polium Leaf Extract and its Phenolic and Flavonoids Content
Author(s) -
Khaled Qabaha,
Thameen Hijawi,
Abdallah Mahamid,
Haneen Mansour,
Naeem Ahmad,
Jehad Abbadi,
Fuad AlRimawi
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23096
Subject(s) - teucrium , antioxidant , chemistry , polyphenol , traditional medicine , anti inflammatory , tumor necrosis factor alpha , flavonoid , food science , biochemistry , pharmacology , biology , lamiaceae , medicine , immunology
Teucrium polium leaf is one of the folkloric medicinal plants used traditionally to treat many diseasesin the Palestinian community. It has antibacterial antioxidant and anti-inflammatory consequences.Present study aims the evaluating the in vitro inhibitory effect of Teucrium polium leaf extracts ontumor necrosis factor-α (TNF-α) using polymorphonuclear cells (PMNCs), in addition to determineits antioxidant and total phenolic and flavonoids contents. Polymorphonuclear cells were withdrawnfrom whole blood according to Histopaque (Ficol-1077) method. Blood cells were cultured in anenriched Roswell Park Memorial Institute (RBMI) medium. The levels of tumor necrosis factor (TNF-α)were determined after 24 h using LPS stimulation. Total phenolic contents, flavonoids contents andantioxidant activity were measured using spectrophotometric method. The TNF-α concentrations werecompared using paired-samples t test. The leaf extracts of Teucrium polium revealed significantreduction in terms of TNF-α levels. The extract contained high phenolic and flavonoids contents andits antioxidant activities were remarkable. The reduced values in the TNF-α levels as affected byTeucrium polium leaf extracts indicate its effect in anti-inflammation. The plant is rich with polyphenoliccompounds and flavonoids and has strong antioxidant activity. The observed anti-inflammatory effectof the extracts under study may be discussed as the influence of the significant presence of the phenoliccompounds and flavonoids.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here