Open AccessAn Efficient Suitable Synthesis for Pyrazole, Pyrimidine Derivatives and Biological Evaluation
Author(s) -
S. Syed Shafi,
P. Subashini,
S. Gajalakshmi,
Vikash Kumar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23095
Subject(s) - chemistry , pyrazole , acetamide , pyrimidine , acetanilide , hydrazine (antidepressant) , guanidine , quinazoline , pyrazoline , organic chemistry , elemental analysis , isoxazole , semicarbazide , proton nmr , antimicrobial , hydrochloride , combinatorial chemistry , stereochemistry , chromatography
Novel quinazoline derivatives were synthesized by reacting isatoic anhydride and 4-amino acetanilide to synthesize N-(4-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)acetamide which in turn reacted with substituted aromatic aldehydes to synthesize novel chalcones.The chalcones were allowed to react with hydrazine hydrochloride and guanidine to form pyrazoline and pyrimidine derivatives, respectively.The newly synthesized compounds were characterized by IR, NMR (1H, 13C), mass and elemental analysis. All the newly synthesizedderivatives were screened for in vitro antimicrobial and antioxidant activities to evaluate their biological potency.