Open AccessImidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line
Author(s) -
Hari Sharan Adhikari,
Aditya Garai,
Chetana Khanal,
Rameshwar Adhikari,
Pravesh Yadav
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23078
Subject(s) - chemistry , chitosan , semicarbazone , imidazole , copper , nuclear chemistry , proton nmr , chelation , in vitro , stereochemistry , biochemistry , organic chemistry
Chitosan oligosaccharide and high molecular weight crab shell chitosan were functionalized asimidazole-2-carboxaldehyde chitosan thiosemicarbazones and their copper(II) complexes weresynthesized. The synthesized compounds were characterized by FT-IR, 13C NMR, EPR spectroscopy,powder X-ray diffraction (PXRD) analysis, elemental analysis and magnetic susceptibilitymeasurements. The low molecular weight chitosan thiosemicarbazones showed higher in vitro inhibitoryactivity as studied by MTT assay against the tumorigenic epithelial Madin-Darby Canine Kidney(MDCK) cell line than the corresponding high molecular weight chitosan derivative. The antitumorigenicenhancement upon the complex formation was revealed by the better inhibitory activity of copper(II)chitosan thiosemicarbazone chelates.