Open AccessMicroencapsulation of Gadolinium Citrate using Silica for Contrast Agent Development
Author(s) -
Annisa Putri Septiani,
Anni Anggraeni,
Ari Hardianto,
Diana Rakhmawaty Eddy,
Husein H. Bahti
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23076
Subject(s) - gadolinium , chemistry , particle size , chromatography , nuclear chemistry , organic chemistry
Gadolinium is a potential T1 contrast agent because it provides a better image for magnetic resonanceimaging (MRI). However, as toxic gadolinium ions can be released from the coordination compounds,it is often encapsulated using silica. Silica-encapsulated gadolinium citrate is a colloid, therefore,encapsulation efficiency should be determined by the standard addition method, not the externalstandard, to minimize errors in the matrix. Silica-encapsulated gadolinium citrate (Gd-C6H5O7@SiO2)was prepared via the Stöber sol-gel method by mixing gadolinium citrate, ethanol, aqua proinjection,tetraethylorthosilicate (TEOS) and ammonia, then the encapsulation efficiency was determined usingthe standard addition method. Particle size analysis revealed that the average size of Gd-C6H5O7@SiO2particles was 1.53 μm having a encapsulation efficiency of 90.44%.