Open AccessSynthesis, Characterization and Biological Screening of Novel Metal(II) Complexes of 2-{[2-(5-Benzoyl-1H-benzotriazol-1-yl)-2-oxoethyl]amino}-5-bromobenzoic Acid
Author(s) -
P. S. Desai,
D.V. Parekh
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23073
Subject(s) - benzotriazole , chemistry , metal , ligand (biochemistry) , chelation , nuclear chemistry , elemental analysis , antibacterial activity , transition metal , infrared spectroscopy , proton nmr , inorganic chemistry , medicinal chemistry , stereochemistry , organic chemistry , bacteria , biochemistry , receptor , biology , genetics , catalysis
In this work, 5-bromoanthranilic acid was condensed with 1-(5-benzoyl-1H-1,2,3-benzotriazole-1-yl)-2-chloro-ethanone to form 2-{[2-(5-benzoyl-1H-benzotriazol-1-yl)-2-oxoethyl]amino}-5-bromobenzoic acid. The newly synthesized ligand and its metal(II) complexeswith first transition metal series (Cu(II), Ni(II), Co(II), Zn(II) and Mn(II)) have been synthesized and characterized by using elementalanalysis, infrared and electronic spectra. The IR spectra, NMR spectra and atomic absorption analysis show that the benzotriazole ligandformed chelates with metal in a 2:1 (ligand:metal) stochiometry. All the metal(II) complexes were screened for their antibacterial activityagainst Gram-positive and Gram-negative bacteria. Among the synthesized metal(II) complexes, Cu(II) complex showed the highestantibacterial activity.