Open AccessIsolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei: Their Anti-lung Cancer Cell and in vivo Anti-aging Activity
Author(s) -
Preeyanuch Manohong,
Nilubon Sornkaew,
Krai Meemon,
Kawita Chumphoochai,
Prasert Sobhon,
Montakan Tamtin,
Jirapast Sichaem,
Withawat Mingvanish,
Choladda Srisuwannaket,
Nakorn Niamt
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23051
Subject(s) - chemistry , palmitic acid , ethyl acetate , phytochemical , in vivo , indole test , antioxidant , biochemistry , fatty acid , biology , microbiology and biotechnology
This study aimed to evaluate the bioactivity and phytochemical investigation in red algae Halymeniadurvillei. The polarity based solvent partition (hexane, ethyl acetate, butanol and water) of H. durvilleiethanolic crude were used for characterization. The present results of the ethyl acetate extract of redalga H. durvillei generated a 3-(hydroxyacetyl)indole (1), indole-3-carboxylic acid (2) as well as twofatty acids viz. palmitic acid (3) and α-linoleic acid (4). The viability against lung cancer cells ofcompounds 1 and 2 showed moderate activities against the A549 cell line with inhibition percentagesof 12.97% and 25.81%, respectively. Analysis of the dose response of C. elegans anti-aging assayindicated that the survival rate of compound 1 was 12.62% while it was 11.04% for compound 2.Furthermore, H. durvillei isolation was used as an antioxidant, anti-cancer cell and anti-aging resource.