Open AccessSynthesis of New Schiff Base of 1,3-Oxazine and 1,3-Thiazine Derivatives Derived from 4-Phenyl Substituted Chalcones and Evaluation of their Antibacterial Activity
Author(s) -
Anupama Sharma,
Sarita Khaturia,
Har Lal Singh
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23050
Subject(s) - thiazine , chemistry , schiff base , antibacterial activity , homo/lumo , combinatorial chemistry , carbon 13 nmr , proton nmr , derivative (finance) , staphylococcus aureus , stereochemistry , organic chemistry , bacteria , molecule , biology , financial economics , economics , genetics
Oxazine and thiazine heterocycles have distinctive interests due to their important class of natural andnon-natural products and exhibit high biological activities in the pharmaceutical and biological fields.This work was planned to synthesize Schiff base of 1,3-oxazine and 1,3-thiazine derivative from4-phenyl substituted chalcones. The structures of the newly synthesized targeted compounds wereestablished from UV, IR, 1H NMR, 13C NMR and DFT calculations. The molecular propertiesHOMO-LUMO energy, energy gap, softness and harness were calculated using DFT/B3LYP/6-311G(d,p) basis set. in vitro Antibacterial activities of Schiff bases of 1,3-oxazines and 1,3-thiazinesderivatives were investigated against Gram-positive (Staphylococcus aureus) and Gram-negativebacteria (Escherichia coli) and compared with each other. It was found that thiazine derivatives showedhigher activity.