Open AccessSynthesis and Characterization of 3-Substituted Indole Derivatives as Novel Mannich Bases
Author(s) -
Emine Erdag
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23035
Subject(s) - chemistry , indole test , mannich reaction , microwave , microwave irradiation , elemental analysis , carbon 13 nmr , proton nmr , organic chemistry , characterization (materials science) , combinatorial chemistry , catalysis , nanotechnology , physics , materials science , quantum mechanics
In this study, ten 3-substituted indole derivatives at the 3rd position of indole nucleus were synthesizedvia Mannich reaction with microwave assisted synthesis and the conventional reflux heating method.Microwave assisted synthesis is more preferrable than reflux method since the microwave irradiationlead to a higher product yields with better purity and improved energy efficiency with shortenedreaction time. The structures of 3-substituted indole derivatives were characterized by FT-IR, elementalanalysis, 1H NMR and 13C NMR spectroscopy