Open AccessAntimicrobial, Structure-Activity Relationship and Computational Studies of Some Synthesized Chalcone Derivatives
Author(s) -
Mizanur Rahman Badal,
Tarikul Islam,
Reshma Parvin,
Md. Abul Khaer Morol,
Md. Maniruzzaman,
Mohammad Yousuf,
Ershad Halim
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23028
Subject(s) - chemistry , chalcone , antimicrobial , pyrimidine , propane , pyran , organic chemistry , medicinal chemistry , stereochemistry
Several chalcones viz. 1,3-diaryl-2-propane-1-one (1a), 3-(4-hydroxy phenyl)-1-phenyl-2-propane-1-one (1b), 3-(4-amino-phenyl)-1-phenyl-2-propane-1-one (1c) and their derivatives 2-ethoxy-4,6-diphenyl-4H-pyran-3-carboxylic acid ethyl ester (2a), 4-(4-hydroxy-phenyl)-7,7-dimethyl-2-phenyl-4,6,7,8-tetrahydro-chromen-5-one (2b) and 7-(4-amino-phenyl)-5-phenyl-1,5-dihydropyrano[2,3-d]pyrimidine-2,4-dione (2c ) have been synthesized following both conventional and microwaveirradiation methods. The structures of the isolated compounds were elucidated on the basis ofUV-visible, FTIR, 1H NMR spectral data. The antimicrobial results showed some remarkable factsabout the structure–activity relationship, which states that the electronic atmosphere around the chalconederivative moieties and substituents considerably affect the antimicrobial potential of the synthesizedcompounds. Theoretical calculation as well as antimicrobial activity of the compounds were alsostudied.