Open AccessAntimicrobial and Drug Releasing Studies of Novel Acrylate Polymer based on Triazine
Author(s) -
P. Uma,
J. Suresh,
Revathi Selvaraj,
A. Arun
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23018
Subject(s) - chemistry , acryloyl chloride , acrylate , moiety , comonomer , chalcone , monomer , polymer , acrylic acid , organic chemistry , polymer chemistry
This work is focused on the synthesis and characterization of versatile acrylate polymer of chalconebased triazine for their antibacterial activity and cumulative drug release behaviour studies. The novelacrylate monomer 4-(3-(4-((4-(4-(3-(4-((7-chloroquinolin-4-yl)amino)-phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)oxy)phenyl)-3-oxoprop-1-en-1-yl)phenylacrylate (SCP) is from novel chalcone and acryloyl chloride. Homo and copolymers of SCPwere prepared using acrylic acid and hydroxyethyl acrylate. Physical characterization confirms theformation of the above compounds. Prepared drug molecules possess chalcone moiety as well asquinoline so it has the greater effect to inhibit the growth of the Gram-negative bacteria (15.63 ± 0.4μg/mL) was confirmed by MIC method. The weight average molecular weight of the polymer is10,000 g/mol. The polymer decomposes at 325 ºC. Drug releasing in vitro behaviour of the synthesizeddrug is controlled by the nature of comonomer, pH and the temperature.