Open AccessSynthesis of Melamine Core Starburst Polyamide G1 Dendrimer and its Antibacterial and Antioxidant Activities
Author(s) -
Periyasamy Balu,
Indira Viswambaran Asharani,
Dhakshanamurthy Thirumalai
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.22991
Subject(s) - chemistry , dendrimer , hydroxymethyl , melamine , monomer , dpph , antibacterial activity , nuclear chemistry , polymer chemistry , antioxidant , organic chemistry , polyamide , carbon 13 nmr , polymer , biology , bacteria , genetics
A novel polyamide first-generation dendrimer 7 was synthesized from new methodology under mildreaction conditions. The AB2 adduct, ethyl 2-[N-[2,2-bis(hydroxymethyl)propionyl]amino]ethylate(3), was prepared from 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) and glycine as a linker. Further,G1 dendrimer 7 was synthesized by coupling melamine (5) with monomer 3. The structural elucidationsof all the compounds were confirmed by FTIR, 1H & 13C NMR and HRMS. The G1 dendrimer wasfound to exhibit significant antibacterial activity against S. aureus and E. cloacae and antioxidantactivity by DPPH scavenging method when compared to the standard, ascorbic acid.