Open AccessDevelopment of Chitosan-Collagen/Substituted Hydroxyapatite-Polypyrrole Biocomposite with Prospective Application in Bone Tissue Engineering Scaffolds
Author(s) -
P. Lavanya,
N. Vijayakumari,
R. Sangeetha,
G. Priya
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.22943
Subject(s) - biocomposite , polypyrrole , chitosan , scaffold , chemistry , tissue engineering , osteoblast , materials science , chemical engineering , nuclear chemistry , biomedical engineering , composite material , composite number , polymer , organic chemistry , biochemistry , in vitro , medicine , polymerization , engineering
An innovative hybrid based on chitosan-collagen/copper, manganese substituted hydroxyapatitepolypyrrole(CS-COL/CMHA-PPY) was developed in present study to further enhance the surfacemorphology of regenerative medicine scaffolds by combining the synthesized copper, manganesesubstituted hydroxyapatite (CMHA) and polypyrrole with the chitosan and collage solutionaccompanied by solvent casting techniques. The fabricated biocomposite was characterized usingFTIR, XRD and SEM techniques. It investigated the effects of CMHA and polypyrrole on the scaffold'sphysico-chemical characteristics like swelling proportion, degradation, and mechanical nature. TheCS-COL/CMHA-PPY biocomposite demonstrated lower deterioration rate and higher mechanicalproperties according to the chitosan-collagen and CS-COL/CMHA biocomposite. MTT assay conducteda tentative evaluation of the tissue engineering and cytotoxicity of the chitosan-biocomposite scaffoldutilizing osteoblast cells. Tests demonstrated no toxicity, so osteoblast cells were bound to thebiocomposite pore surfaces so propagated. Such results indicated that the scaffold established has thepreconditions which can be used as a scaffold for the reconstruction of bone tissue.