Open AccessAdvanced Dosage Form Design: Role of Modified Natural Gums
Author(s) -
Gayatri Devi,
Malkiet Kaur,
Manju Nagpal,
Ameya Sharma,
Vivek Puri,
Gitika Arora Dhingra,
Minaxi Arora
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.22937
Subject(s) - chemistry , drug delivery , locust bean gum , natural polymers , dosage form , solubility , xanthan gum , inert , crystallinity , polymer , organic chemistry , chromatography , materials science , rheology , composite material , crystallography
Gums are naturally occurring segments in plants, which are cheap and abundant. Natural gums and their derivatives are widely used in apharmaceutical dosage form. These natural materials possess several advantages over synthetic ones being chemically inert, non-toxic,low cost and biodegradable. However, quick degradation in the body, poor mechanical properties and low solubility are few disadvantages.To overcome these disadvantages, natural gums are modified by applying different chemical modification procedures. The modificationof gums is done via various methods such as changing functional groups of gum, cross-linking with ions, grafting with polymers, sulfation,phosphorylation and thiolation. Modification of gums results in some superior properties which can be used in drug delivery applications.For example, change in crystallinity, improved solubility, stability, and improved mechanical properties are of use in development of modifieddrug delivery systems. Modified gums help to achieve pH dependent delivery and sustained delivery along with improved release kineticsof the drug. Current review covers various types of modifications in general and research literature on various medications of differentgums (locust bean gum, cashew gum, moringa gum, xanthan gum, etc.). The modified natural gums and their derivatives can be theprospective carriers in the controlled drug delivery of drugs.