Open AccessFabrication and Evaluation of Mini Tablet Filled Capsules to Treat Transient Ischemic Attack
Author(s) -
Sachin Naik,
M. Purushothaman,
K. B. Chandrasekhar
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.22929
Subject(s) - salicylic acid , chemistry , mucilage , gelatin , irritation , chromatography , plantago ovata , clopidogrel , nuclear chemistry , organic chemistry , aspirin , medicine , biochemistry , ecology , horticulture , immunology , biology
In this work, mini tablets filled hard gelatin capsules were fabricated for a fixed-dose therapy fortransient ischemic attack (TIA). Clopidogrel besylate (CB)-75 mg and acetyl salicylic acid (ASA)-75mg were utilized in this work. Among the mini-tablets (MTs) clopidogrel besylate, was uncoatedconventional mini-tablets, whereas acetyl salicylic acid was enteric-coated. Acetyl salicylic acid gastricirritation was overcome by using Plantago ovata seed mucilage as a binder in all mini-tablets. Bothtypes of mini-tablets were filled in hard gelatin capsules. Clopidogrel besylate and acetyl salicylicacid compatibility with excipients used were evaluated, all the mini-tablets were judged forpost-compression constraints. The prepared mini-tablets confirmed no interaction by FTIR and DSCstudies. All the mini-tablets passed the physico-chemical constraints. Clopidogrel besylate was releasedfrom the dosage form within 45 min, whereas enteric-coated acetyl salicylic acid mini-tablets resist torelease in an acidic environment and released within 45 min in an alkaline buffer. Even the filledcapsules were also passed all the parameters evaluated. The study concludes that by using P. ovata asa binder in making tablets will resolve the issues related to gastric irritation.