Open AccessStudies on Inclusion Complexes of β-Cyclodextrin with Some Metal Complexes of Isatinylsemicarbazone and Isatinylthiosemicarbazone
Author(s) -
Rakesh Kumar,
Sanjay Kumar,
Manju Bala
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22993
Subject(s) - chemistry , metal , antibacterial activity , bacillus subtilis , cyclodextrin , tetrahedral molecular geometry , nuclear chemistry , crystallography , conductance , magnetic susceptibility , stereochemistry , bacteria , organic chemistry , genetics , biology , mathematics , combinatorics
The complexes of Co(II), Ni(II), Zn(II) and Cd(II) with isatinylsemicarbazone (IstscabH) andisatinylthiosemicarbazone (IsttscabH) of composition ML2·2H2O [M = Co(II) or Ni(II) and LH =IstscabH or IsttscabH] and ML2 [M = Zn(II) or Cd(II) and LH = IstscabH or IsttscabH] have beensynthesized and their antibacterial activity has been investigated. Their inclusion complexes withβ-cyclodextrin (β-CD) having composition [ML2(β-CD)·2H2O] or M(C60H88N8O39S2)], [M = Co(II) orNi(II) and LH = IstscabH or IsttscabH] and [ML2(β-CD) or M(C60H84N6O-37S2)], [M = Zn(II) or Cd(II)and LH = IstscabH or IsttscabH] have also been isolated in solid states. All the synthesized metalcomplexes have been characterized by analytical data, molar conductance, magnetic susceptibility,electronic and infrared spectral studies. The tetrahedral geometry for Zn(II) and Cd(II) and octahederalgeometry for Co(II) and Ni(II) have been assigned on the basis of magnetic susceptibility, UV electronictransitions and IR spectral bands assignments. The structures are retained in inclusion products. Abiological activity of Schiff bases, their metal complexes and inclusion products for bacteria Escherichia.coli, Bacillus subtilis and Staphylococcus aureus have been screened and activity explained.