Open AccessFabrication and Characterization of Chitosan-Polypyrrole/Strontium-Magnesium Substituted Hydroxyapatite Biocomposite with Potential Application in Tissue Engineering Scaffolds
Author(s) -
P. Lavanya,
N. Vijayakumari,
R. Sangeetha,
G. Priya
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22936
Subject(s) - biocomposite , biocompatibility , chemistry , polypyrrole , chitosan , osteoblast , biomineralization , alkaline phosphatase , chemical engineering , scaffold , nuclear chemistry , materials science , biomedical engineering , biochemistry , organic chemistry , composite material , composite number , polymer , medicine , engineering , in vitro , polymerization , enzyme
Biocomposite scaffolds of strontium-magnesium substituted hydroxyapatite (SMHA) with a mixtureof chitosan/polypyrrole (CS-PPY) have been prepared by solvent casting method. The synthesizedSMHA nanoparticles and biocomposite scaffold were characterized by FTIR, XRD and SEMtechniques. The SEM morphology revealed the porous structure of the scaffolds designed for themuticomponents. The biomineralization and cell viability of the biocomposite were assessed via alkalinephosphatase activity and MTT assay on the osteoblast cell line. The study demonstrated improveddifferentiation and mineralization of osteoblast cells in the designed biocomposite scaffolds. The dyestained fluorescent microscopic photographs apparent the good scattering and permeability of cellsonto the scaffolds. However, biocomposite demonstrated good antibacterial activity and the excellentbiocompatibility against osteoblast cells offers a possible route for the production of a biocompositeas a viable replacement for regenerative medicine scaffolding substance.