Open AccessSynthesis and Characterization of Mesoporous Silica Carrier Releasing Valsartan
Author(s) -
Frezah J. Muhana,
Rana AbuHuwaij,
Nooman A. Khalaf,
Fawwaz I. Khalili,
Naeem Shalan
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22901
Subject(s) - valsartan , chemistry , mesoporous silica , fourier transform infrared spectroscopy , mesoporous material , dissolution , chemical engineering , adsorption , controlled release , powder diffraction , drug delivery , drug carrier , thermogravimetric analysis , mcm 41 , nuclear chemistry , organic chemistry , crystallography , catalysis , medicine , blood pressure , engineering , radiology
The aim of the present study is to synthesize a mesoporous silica MCM-48 and loading it with the poorly soluble drug valsartan. TheMCM-48 was characterized by Brauner-Emmett-Teller surface area analyzer, scanning electron microscope, powder X-ray diffraction,thermal gravimetric analysis and Fourier transform infra-red (FTIR). The exact loading capacity was found to be 40.12%. in vitro dissolutionstudies at physiological conditions demonstrated controlled release of 57.2% valsartan over 240 min. The controlled dissolution wasattributed to the incomplete amorphization of crystalline valsartan by MCM-48 as evidenced by PXRD studies. The interactions betweenthe mesoporous silica surface and drug molecules were evidenced by FTIR studies and the diffusion of therapeutic agent moleculesthrough the silica pores. The results of the present study confirmed that the controlled adsorption and liberation of valsartan demonstrateda long-term release, which is important for its antihypertensive activity. Moreover, the structural properties of mesoporous silica assuredthe feasibility of designing reliable drug delivery systems by appropriate choice of the carrier