Open AccessIsolation and Characterization of Bioactive Anti-inflammatory Flavonoids from Arisaema tortuosum Tubers
Author(s) -
Priyanka Chakraborty,
Kamalika Mazumder,
Nripendra Nath Bala,
Sudipta Das
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22895
Subject(s) - chemistry , anti inflammatory , traditional medicine , chemical constituents , in vivo , fraction (chemistry) , column chromatography , in vitro , flavonoid , chromatography , antioxidant , pharmacology , biochemistry , biology , microbiology and biotechnology , medicine
Present study was focused on the isolation and characterization of the anti-inflammatory compound(s)from the methanolic extracts of Arisaema tortuosum tuber by column chromatography, TLC, FT-IR,1H, 13C NMR and HR-MS. Among all the fractions obtained A. tortuosum fraction 3 (PC-1) andfraction 5 (PC-2) showed significant in vivo anti-inflammatory activity. This study endorsed that theisolated bioactive compound PC-2 showed better anti-inflammatory activity at a dose of 25 mg/KgBW. The results indicate that PC-2 and PC-1 methanolic extract of A. tortuosum tuber may be competingfor the tent in the therapy of inflammatory ailments.