Open AccessAmmonium Chloride: An Efficient and Environmentally benign Catalyst for Knoevenagel Condensation of Carbonyl and Active Methylene Compounds
Author(s) -
Tasqeeruddin Syed,
Yahya I. Asiri,
M. Mujahid A lam
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22879
Subject(s) - chemistry , knoevenagel condensation , methylene , catalysis , organic chemistry , yield (engineering) , environmentally friendly , ammonium chloride , ammonium acetate , chloride , ecology , materials science , high performance liquid chromatography , metallurgy , biology
In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation ofvarious carbonyl and active methylene compounds in ethanol at a moderate temperature in the presenceof a catalytic amount of an efficient, environmentally benign and inexpensive ammonium chloride isreported. Simple reaction procedure, economic and ecofriendly catalyst, mild reaction conditions andgood to excellent yield of the products are the characteristic features of this study. The non-extractiveworkup/purification, economic and environmentally benign catalyst make this operationallystraightforward procedure affordable for large scale.