Open AccessIsoxazoles-A Biocompatible Radical Scavenging Agents: Citrus Juice Mediated Environmentally Benign Synthesis and Characterization
Author(s) -
K. R. Raghavendra,
M. G. Prabhudeva,
A. Dileep Kumar,
K. Ajay Kumar,
H. Jayadevappa
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22871
Subject(s) - chemistry , dpph , antioxidant , hydroxylamine , hydroxyl radical , scavenging , isoxazole , organic chemistry , bifunctional , combinatorial chemistry , catalysis
This study demonstrates the efficient eco-friendly synthesis of a series of isoxazole derivatives 5a-hthrough (3+2) annulation of chalcones 3a-h and hydroxylamine (4) in citrus juice medium. Thesynthesized compounds were characterized by spectroscopic and CHN analysis, and assessed in vitrofor their antioxidant susceptibilities by DPPH and hydroxyl radical scavenging assays. The resultshows that compounds 5a, 5b, 5d and 5h have excellent DPPH and hydroxyl radical scavengingactivity in both assays and therefore these molecule could serve as potent antioxidant agents.