Open AccessAn Efficient Synthesis of Thiophene Conjugated Benzothiazepines: in vitro Screening for their Antimicrobial Activity
Author(s) -
K. R. Raghavendra,
P. K. Sudeep,
K. Ajay Kumar,
H. Jayadevappa
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22861
Subject(s) - antimicrobial , chemistry , thiophene , ciprofloxacin , nystatin , in vitro , conjugated system , bacteria , combinatorial chemistry , organic chemistry , biochemistry , antibiotics , polymer , biology , genetics
A series of novel thiophene conjugated benzothiazepines were synthesized by the reaction of chalconeswith 2-aminobenzenethiol in citrus juice medium. The new compounds were characterized byspectroscopic studies. Results of in vitro antimicrobial evaluation of newly synthesized compounds5a-j shows that the compounds 5a and 5c have excellent antimicrobial inhibition in the range of 12.5-25.0μg/mL against bacteria S. aureus, E. coli, P. aeruginosa and fungi A. niger, A. flavus organismscomparable to ciprofloxacin and nystatin and therefore these compounds might acts as lead moleculesas antimicrobial agents.