Open AccessSynthesis and in vitro Cytotoxicity Study of Novel 4-Substituted Quinazolines Encompassed with Thiazolidinone and Azetidinone
Author(s) -
Akash Jori,
Sheshagiri R. Dixit,
Gurubasavraj V. Pujar
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22837
Subject(s) - chemistry , dpph , antioxidant , cytotoxicity , titration , mtt assay , in vitro , proton nmr , stereochemistry , combinatorial chemistry , nuclear chemistry , organic chemistry , biochemistry
A series of quinazolines encompassed with thiazolidinone and azetidinone have been synthesized andevaluated for their antioxidant, anticancer and DNA binding studies. All the synthesized compoundswere characterized by IR, 1H & 13C NMR and mass spectra. Antioxidant activity was carried out using% free radical scavenging by DPPH assay. Compounds 4b, 5b and 5d have shown better antioxidantactivity (60, 67 and 66%, respectively) among the tested compounds. Compounds having % freeradical scavenging activity more than 55% were evaluated for anticancer activity by MTT assay towardscell lines A-549 (lung carcinoma) and MDA-231 (human breast cancer). Results revealed that thetested compounds exhibited moderate to low anticancer activity. Further, DNA binding activity wasstudied by absorption titration method for all the synthesized compounds, and compound 5b showed agood binding constant of 70.05 and % hyperchromicity of 82.93%.