Open AccessNew Copper(II) Complexes of Pyridine-2-carboxaldehyde-N-(2-pyridyl)hydrazone and 2-Hydroxy-1-naphthaldehyde-semicarbazone: Synthesis, Characterization, DNA Binding and Antimicrobial Activity Studies
Author(s) -
Oinam U-wang,
Raj K. Singh,
Usam Ibotomba Singh,
Ramina,
Thiyam Ramsing Singh,
Toka Swu,
Chingakham Brajakishor Singh
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22827
Subject(s) - chemistry , triclinic crystal system , semicarbazone , hydrazone , monoclinic crystal system , copper , pyridine , crystallography , stereochemistry , square pyramidal molecular geometry , crystal structure , electron paramagnetic resonance , methylene , medicinal chemistry , organic chemistry , nuclear magnetic resonance , physics
Two new copper(II) complexes of pyridine-2-carboxaldehyde-N-(2-pyridyl)hydrazone[Cu(PCPH)(H2O)2](NO3)(H2O)2 (1) and 2-hydroxy-1-naphthaldehyde-semicarbazone[Cu(II)(HNSC)H2O]·NO3·H2O (2) have been synthesized and characterized by spectroscopic techniquesand single crystal X-ray diffraction study. Complex 1 crystallized as square pyramidal coordinationcomplex in triclinic crystal system while complex 2 crystallized as square planar complex in monocliniccrystal system. EPR spectral patterns are of normal order of energy levels, i.e. x2-y2 >> z2 > xy > xz, yz,with partial covalent character. Both copper(II) complexes were found to be groove binding tocalf-thymus DNA and showed activity against E. coli, S. aureus, B. cereus and E. faccium.