Open AccessComplexes of Pyrimidine Thiones: Mechanochemical Synthesis and Biological Evaluation
Author(s) -
Pooja Sethi,
Rajshree Khare,
Renuka Choudhary
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22813
Subject(s) - chemistry , ligand (biochemistry) , pyrimidine , denticity , metal , proton nmr , infrared spectroscopy , stereochemistry , infrared , magnetic moment , crystallography , thermogravimetric analysis , medicinal chemistry , organic chemistry , biochemistry , physics , receptor , optics , condensed matter physics
A new series of metal complexes with 1-(2-methylphenyl)-4,4,6-trimethyl pyrimidine-2-thione (2-HL1)and 1-(4-methylphenyl)-4,4,6-trimethyl pyrimidine-2-thione (4-HL2) ligands, [M(mppt)2(H2O)n](M(II) = Cu, Mn, Co; n = 2 and M(II) = Ni, Zn; n = 0) have been synthesized using mechanochemicalprotocol. The complexes have been framed as [M(mppt)2(H2O)n] due to 1:2 (metal:ligand) nature ofthese metal complexs. Structures have been further confirmed on the basis of elemental analysis,Magnetic susceptibility measurements, electronic, infrared, far infrared, proton NMR, Mass spectralmoment and thermogravimetric analysis studies. The infrared spectral data suggested that ligand behavesas a bidentate, coordinating through – N (endocyclic) and – S (exocyclic) donor atoms. All thecompounds have also been screened for antibacterial and DNA photocleavage potential. Ligandscomplexed with Mn and Ni metals have shown the effect of substitution on their biological potentials.It was found that substitution at 4th or para position makes the ligand and its metal complexes havebetter antibacterial and DNA photocleaving agents.