Open AccessSolid Phase Synthesis and Antimicrobial Activity of Novel Triazolo[1,5-a]pyrimidine Derivatives
Author(s) -
Shobhana A. Gadara,
Kartik D. Ladva
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22793
Subject(s) - chemistry , aspergillus niger , bacillus subtilis , antimicrobial , escherichia coli , antibacterial activity , pyrimidine , staphylococcus aureus , penicillium , nuclear chemistry , pseudomonas aeruginosa , aspergillus fumigatus , organic chemistry , bacteria , stereochemistry , food science , microbiology and biotechnology , biochemistry , genetics , gene , biology
A new series of triazolo[4,3-a]pyimidine derivatives via solid phase multicomponent reaction between 3-oxo-N-(4-(3-oxomorpholino)-phenyl)butanamide, aromatic aldehyde and aminoazole is reported. All the synthesized compounds have been characterized by elementalanalysis and spectral analyses. Moreover, the synthesized compounds were also screened for their antibacterial activity againstStaphylococcus aureus MTCC-96, Escherichia coli MTCC-443, Bacillus subtilis MTCC-441, Pseudomonas aeruginosa MTCC 1688,and antifungal activity against Aspergillus niger MTCC-282 and Penicillium sp. at different concentration and compared with standardsdrugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro-broth dilution method.