Open AccessSynthesis, Characterization and Biological Evaluation of Some Novel Regioisomers of Ropivacaine Analogues: An Anaesthetic Drug
Author(s) -
S P Sharavanan,
C.S. Venkatesan,
D. Raju,
S. Kabilan
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22722
Subject(s) - chemistry , dpph , substituent , ropivacaine , antioxidant , mtt assay , stereochemistry , in vitro , antibacterial activity , biological activity , cytotoxicity , bacteria , combinatorial chemistry , organic chemistry , biochemistry , pharmacology , medicine , biology , genetics
A series of ropivacaine analogues were synthesized by altering the methyl group substituent in the aromatic ring. The synthesizedcompounds (2a-f and 3a-f) were characterized by using IR, NMR and HRMS analysis and then compounds 3a-3f were screened in vitroanticancer (MTT assay) activity against breast cancer cell line (MCF-7), antibacterial and antioxidant (DPPH scavenging assay) studies.The biological studies revealed that the compounds 3c and 3f have shown a good inhibitory activity against MCF-7 cell line. Compounds3e, 3b, 3c and 3f showed moderate antioxidant activity. There was no inhibition observed against both Gram-positive and Gram-negativebacteria.