Open AccessSynthesis, Characterization, Biological Evaluation and Molecular Docking Studies of Some Oxazinyl-Thiazolidinone Derivatives
Author(s) -
R. Rajalakshmi,
R. K. Santhi,
Thangaraj Elakkiya
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22710
Subject(s) - chemistry , dpph , docking (animal) , antioxidant , in vitro , combinatorial chemistry , stereochemistry , carbon 13 nmr , scavenging , proton nmr , organic chemistry , biochemistry , medicine , nursing
A series of new 4-thiazolidinone derivatives of 2-(4-chlorophenyl)-3-(6-(thiophen-2-yl)-4-p-tolyl-4H-1,3-oxazin-2-yl)-thiazolidin-4-one (7h-m) are synthesized because of its wide range of biological activities.1H & 13C NMR, IR studies wereapplied for the elucidation of all the synthesized compounds. All the synthesized compounds have been tested for antidiabeticand antioxidant activity in vitro method against standard. The analogs 7h-m was evaluated for α-amylase and α-glucosidaseinhibitory potential. The structures of all the compounds have been screened for antioxidant activity using DPPH radicalscavenging assay, NO scavenging method. Molecular docking studies were accomplished in addition to understand thebinding affinity of those compounds with PDBID 2HR7 which showed that the synthesized derivatives bind in the livelybinding site of the target protein