Open AccessDNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes
Author(s) -
Murugan Selvamariammal,
Maruthappan Malarvizhi
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22700
Subject(s) - chemistry , pyrazolone , ligand (biochemistry) , isatin , metal , octahedron , titration , transition metal , stoichiometry , schiff base , chelation , crystallography , stereochemistry , inorganic chemistry , medicinal chemistry , organic chemistry , receptor , crystal structure , biochemistry , catalysis
Some novel series of 5-chloro isatin and 4-aminoantipyrine based Schiff bases with transition metal(II)complexes of (Cu, Co, Ni and Zn) have been prepared and characterized by physical, analytical andspectral data. The synthesized ligand behaves as a neutral tridentate is confirmed by spectral techniques.During the complexation, the stoichiometry ratio 1:2 (metal:ligand) is followed and an octahedralarrangement is adopted by all the metal complexes. The calf-thymus DNA interacts with complexesvia an intercalative mode is studied by electronic absorption titration. Moreover, all these synthesizedmetal(II) complexes were tested against a set of bacterial and fungal strains reveals that complexesexhibit better activity than free ligand.