Open AccessAnnonaine an Alkaloid from the Leaves of Custard Apple (Annona squamosa): A Comprehensive Review on its Phytochemicals and Pharmacological Activities
Author(s) -
Sasmita Dash,
Biswakanth Kar,
Nityananda Sahoo,
Gurudutta Pattnaik
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22696
Subject(s) - annona squamosa , custard apple , annona , annonaceae , traditional medicine , phytochemical , aporphine , chemistry , phytochemistry , botany , alkaloid , biology , horticulture , medicine
Annona squamosa is most widely distributed in tropical and subtropical region native to tropical America comes under the Annonaceaefamily. It is a widely used tree having edible fruits called as custard apple which is eatable. Annona squamosa plant also contains 35-42mg/100 g of vitamin C and significant value of nutrient like thiamine, amino acid, riboflavin, niacin, calcium, potassium and dietaryfibers. It also contains the phytoconstituents like diterpenes, alkaloids, cyclopeptides and annonaceous acetogenins proved by phytochemistryinvestigations. The plant Annona squamosa show a number of pharmacological activities like insecticidal, anticancer, hypoglycemic,antioxidant, antimalarial, analgesic and wound healing activity. The vermicidal effect of leaves is responsible for the treatment of tumors,wounds and other skin infections. A number of alkaloids were isolated from the leaves of plant. Most of them belong to aporphine groupof alkaloids. Among all the phytoconstituents an alkaloid Annonaine, plays a vital role for its biological activity. The present reviewrepresents the phytochemical constituents, biological action, traditional as well as medicinal uses of Annona squamosa. Sugar applemight be the better explored plant part used in treatment of many disorders and the present critical study will hopefully provide a diseasefree and healthy life to the human society.