Open AccessPotential Antifungal Activity against Pythium insidiosum of Isoflavonoids from the Stems of Dalbergia cultrata
Author(s) -
Thurdpong Sribuhom,
Yordhathai Thongsri,
Chavi Yenjai
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22690
Subject(s) - formononetin , chemistry , biochanin a , antifungal , isoliquiritigenin , pythium , daidzein , traditional medicine , microbiology and biotechnology , biochemistry , botany , genistein , biology , medicine , endocrinology
Chemical investigation of Dalbergia cultrata Grah. stems growing in Thailand resulted in the isolationand characterization of 14 known compounds, including tectorigenin (1), calycosin (2), pratensein(3), afromosin (4), irilin D (5), biochanin A (6), daidzein (7), formononetin (8), 8-O-methylretusin (9),7,3′-dihydroxy-5′-methoxyisoflavone (10), (3S)-sativanone (11), (3S)-violanone (12), erycibenin D(13) and isoliquiritigenin (14). Their structures were established mainly based on NMR spectroscopictechniques and physical properties. The isolated compounds were evaluated for antifungal activityagainst Pythium insidiosum using disc diffusion assay. Antifungal drugs available now are not effectiveto treat this microorganism. It was found that compound 1 exhibited stronger antifungal activity thanamphotericin-B standard with an MIC value of 10 μg/disc.