Open AccessSynthesis of Spirohydantoins and Schiff Bases of Indenoquinoxalinones and Indenopyridopyrazinones
Author(s) -
Jeong Sup Song,
Song Mi Bae,
HeeAn. Shin,
DaiIl Jung,
Jong Hyun Cho
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22679
Subject(s) - chemistry , schiff base , acetonitrile , ninhydrin , ammonium , salicylaldehyde , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , amino acid
The main structure of many compounds containing spirohydantoin and Schiff bases ofindenoquinoxalines and indenopyridopyrazinones expose valuable pharmacological properties. Herein,an effective synthesis and stereochemistry of indenoquinoxalinones (2a, 2b+bi~2d+di) andindenopyridopyrazinones (2e+ei~g+gi) via the reaction of ninhydrin with desirable diamines is reported.We synthesized the corres-ponding spirohydantoins (3a, 3b~d and 3bi~di) from synthesizedindeno[1,2-b]quinoxalinones and indeno[1,2-b]pyrido[3,2-e]pyrazinones with the standardBucherer-Bergs conditions (KCN, ammonium carbonate, acetonitrile, refluxing, without NaHSO3).And also synthesized the azomethine analogs (4~8+8i) of tetracyclic indeno[1,2-b]quinoxalinones asa Schiff base.