Open AccessIdentification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy
Author(s) -
M. C. Rao,
R. Chenna Krishna Reddy,
K. B. Chandra Sekhar,
Y. V. R. Reddy
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22665
Subject(s) - finasteride , raman spectroscopy , chemistry , dosage form , spectroscopy , chromatography , analytical chemistry (journal) , medicine , optics , prostate , physics , cancer , quantum mechanics
A simple FT-Raman spectroscopic method was developed for identification of finasteride polymorph form in finished dosage form.Finasteride polymorph form I was used in the tablet preparation and the weight fraction of finasteride in tablet was only about 0.023. Themethod was successfully used to identify the polymorphic form of finasteride in tablet and also to detect up to a level of about 15% of theother polymorph of finasteride present in the solid dosage. The dosage form was characterized by different techniques i.e. powdered X-raydiffraction, infrared spectroscopy and Raman spectroscopy. Based on literature survey, only Raman spectroscopy method is able toidentify the polymorph of finasteride in dosage form.