Open AccessSolution and Solid State Study of Nickel(II) Ternary Complexes Containing 5-Aminolevulinic Acid Drug and Amino Acids
Author(s) -
Salhah D. AlQahtani
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22658
Subject(s) - chemistry , nickel , ligand (biochemistry) , inorganic chemistry , stability constants of complexes , histidine , thermogravimetric analysis , crystallography , nuclear chemistry , amino acid , medicinal chemistry , stereochemistry , organic chemistry , ion , biochemistry , receptor
Solution equilibria of the systems Ni(II)-5-aminolevulinic acid as ligand (A) and the amino acids[alanine (Ala), valine (Val), methylamine (Met), imidazole (Imi), Histidine (His), serine (Ser), cysteine(Cys) and penicillamine (Pen)] as ligands (L) have been studied pH-metrically. The stability constantsof mixed ligand complexes were calculated with I = 0.10 mol L-1 KNO3 using HYPERQUAD programat 25 ± 0.1 ºC. The log10 X values showed a higher stabilities for the mixed ligand complexes comparedto the binary analogues. The synthesis and characterization of the new amino acid mononuclear Ni(II)binary complex [NiA] (1) and ternary complex [NiAL] (2) were achieved via molar conductance,elemental analysis UV-vis, IR, 1H NMR, thermal analysis and magnetic moment. The thermogravimetricanalysis of complexes were investigated by TG-DTA suggests that the complexes possess high thermalstability formation and their respective nickel oxide for 1 and nickel sulfide for 2 as final chemicalentities, which are thermally stable. The nickel(II) chelates were found to be non-electrolytes,diamagnetic moments and the geometry around Ni(II) ion in complexes 1 and 2 is square planar