Open AccessSynthesis and Biological Activities of Some Novel Spiro Heterocyclic Pyrrolizidine Derivatives of 11H-indeno[1,2-b]quinoxaline through 1,3-Dipolar Cycloaddition
Author(s) -
Nakul Kumar,
Chhagan Lal,
Braj Raj Singh,
Angik K. Patel
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22630
Subject(s) - chemistry , quinoxaline , knoevenagel condensation , indole test , cycloaddition , pyrrolizidine , benzaldehyde , aldehyde , 1,3 dipolar cycloaddition , indolizine , stereochemistry , organic chemistry , combinatorial chemistry , catalysis
The synthesis of spiropyrrolidines by the Knoevenagel condensation has been reported as highlybioactive natural and synthetic organic products. The synthesis was initiated by Knoevenagelcondensation of indole-2-one with an appropriate benzaldehyde in presence of L-proline to affordspiropyrrolidines. Herein, a design and pathway of syntheses of a library of spiropyrrolidines bearingspiro heterocyclic indeno[1,2-b]quinoxaline-11-one motifs were reported, which also demonstratedan exceptional inhibitory activity against the anticancer cells. A novel series of dispiroindenoquinoxalinepyrrolizidines were synthesized by the condensation of indeno[1,2-b]quinoxalin-11-one and startingmaterial (a product of ninhydrin and aldehyde derivatives). The structure of the synthesized compoundswas established by spectral data.