Open AccessSynthesis, Characterization and Biological Activity of Ni(II), Cu(II) and Fe(III) Complexes Derived from N2,N6-bis(5-Mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide
Author(s) -
Anuroop Kumar,
Netra Pal Singh,
Uma Rani Agrawal,
Krishan Kumar
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22627
Subject(s) - chemistry , deprotonation , pyridine , ligand (biochemistry) , metal , medicinal chemistry , nuclear chemistry , proton nmr , stereochemistry , inorganic chemistry , polymer chemistry , organic chemistry , ion , biochemistry , receptor
Novel metal complexes of the type [M(L)X] (where M= Cu(II), Ni(II) and Fe(III), L =N2,N6-bis(5-mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide, X= Cl−, CH3COO−) weresynthesized by the reaction of pyridine-2,6-dicarboxylic acid and 2-amino-5-mercepto-1,3,4-thiadiazole.The synthesized ligand was reacted in THF with metal salts (Cu, Ni and Fe) to form complexes.Deprotonated ligand shows tridentate nature and coordinate to metal ion to form pincer cavity. In all,complexes metals were surrounded by three nitrogen atom and other site coordinated by other groups(chloride, acetate). All the synthesized complexes were characterized by spectroscopic techniqueslike UV-visible, 13C NMR and 1HNMR, IR spectroscopy, DSC, elemental analysis and molarconductance measurements. The ligand and its metal complexes were tested for antimicrobial activityagainst bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration(MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobialactivity and antifungal activity when tested against bacteria and fungi