Open AccessSynthesis, Spectroscopic Characterization and Antibacterial Assessment of Zirconium(II) and Palladium(II) Complexes of Tetracycline-Salicylaldehyde Mixed Ligand
Author(s) -
Rohit kumar Dev,
Ajaya Bhattarai,
Narendra Chaudhary,
Parashuram Mishra
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22623
Subject(s) - salicylaldehyde , chemistry , ligand (biochemistry) , zirconium , palladium , metal , melting point , stability constants of complexes , schiff base , nuclear chemistry , inorganic chemistry , polymer chemistry , organic chemistry , catalysis , aqueous solution , biochemistry , receptor
Zirconium(II) and palladium(II) mixed ligand metal complexes were synthesized by using an equimolarmixture of tetracycline (Tc) as primary ligand and salicylaldehyde as secondary ligand. The metalcomplexes were characterized by physico-chemical and spectroscopic techniques like CHN analysis,surface tension, pH, conductivity and melting point measurements. The spectroscopic characterizationtechnique includes IR, (1H & 13C) NMR, UV/visible and Mass spectrometry methods. The SEMtechnique determines the surface morphology of the complexes. The thermal and kinetic stability ofthe complexes was obtained from TGA/DTA curves from which the parameters like E*, ΔH*, ΔS* andΔG* have been calculated by using the Coats-Redfern equation. Molecular modeling gives a geometryof the complex which was obtained from Chem 3D Pro. 12.0 software program. The metal complexesof Zr-TcSal and Pd-TcSal have coordinated with tetrahedral and square planar geometry, respectively.The antibacterial susceptibility study of the synthesized metal complexes was done by Kirby-Bauerpaper disc diffusion techniques on S. aureus, E. coli and P. aeruginosa clinical pathogens