Open AccessSynthesis, Characterization and Molecular Docking of 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents
Author(s) -
Panneerselvam Kalaivani,
Jayaraman Arikrishnan,
M. Gopalakrishnan
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22594
Subject(s) - chemistry , acetamide , antimicrobial , antifungal , docking (animal) , stereochemistry , antibacterial activity , carbon 13 nmr , proton nmr , in vitro , combinatorial chemistry , triazole , active site , organic chemistry , biochemistry , bacteria , enzyme , microbiology and biotechnology , medicine , genetics , nursing , biology
In this study, a new series of (E)-N-(4-(3-(3,5-dialkylphenyl)acryloyl)phenyl)-2-(1H-1,2,4-triazol-1-yl)acetamide (32-41) was synthesized, characterized by FT-IR, 1H NMR, 13C NMR and Mass spectralanalysis and evaluated for their in vitro antibacterial and antifungal activities. The docking study ofthe newly synthesized compounds was performed and results showed good binding mode in the activesite of 1T9U protein. The zone of inhibition concentration was tested for the synthesized compoundsagainst five bacterial and three fungal strains. Compounds 34 and 37 have good antibacterial activity.Compounds 3, 4 and 6 shows moderate inhibition against the antifungal activity.