Open AccessOne-Pot Three Component Synthesis of 2-(1H-Benzo[d]thiazole-2-yl)- N-Arylbenzamides in Glycerol Medium
Author(s) -
Swathi Thumula,
Venkatesan Srinivasadesikan,
Ravi K. Kottalanka,
Shalini Rajkumar,
Balajee Ramchandran
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22538
Subject(s) - chemistry , thiazole , hela , docking (animal) , reagent , glycerol , mtt assay , stereochemistry , combinatorial chemistry , nuclear chemistry , organic chemistry , biochemistry , in vitro , medicine , nursing
In this work, a series of 2-(1H-benzo[d]thiazole-2-yl)-N-arylbenzamides is synthesized by using diethylphthalate, anilines and 2-amino-benzenethiol by one-pot three component synthesis in glycerol medium.Phosphoric acid is used as an effective reagent for this one-pot three component reaction. This reactiongot completed in a short time, easy workup and gave an excellent yield in glycerol medium. TheN-arylbenzamides was found to have significant cytotoxic potentials against various cancer cells viz.,A549 (lung cancer), HeLa (cervical cancer) and MCF-7 (breast cancer) using MTT assay. The moleculardocking study is also employed to understand the binding mechanism of N-arylbenzamides againstthe antibacterial target. The docking result shows the binding energy of compound 4a is -8.6 kcal/mol.The binding affinity is a major concern and it shows that Asn and Thr residues have an interaction withcompound 4a.