Open AccessAn Efficient and Green Synthesis of Fluorine Containing Benzo[a]xanthen-11(12H)-ones and Evaluation of their Anticancer Activity
Author(s) -
Sumalatha Jorepalli,
Sreedevi Adikay,
Radha Rani Chinthaparthi
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22503
Subject(s) - chemistry , catalysis , yield (engineering) , naphthalene , fluorine , substrate (aquarium) , condensation , mass spectrometry , solvent , organic chemistry , combinatorial chemistry , chromatography , materials science , oceanography , metallurgy , geology , physics , thermodynamics
A facile and an efficient procedure has been developed by one-pot condensation of naphthalene-diols, fluoro substituted benzaldehydes and cyclic 1,3-dicarbonyl compounds for the synthesis of fluorine containing benzo[a]xanthen-11(12H)-ones under the catalyst and solvent-free conditions. All the synthesized compounds were characterized by IR, NMR (1H & 13C) and mass spectrometry. Several advantages offer the present approach, such as, shorter reaction time, low cost, anticipation of toxic solvents and catalyst, higher yield of products and durability of substrate range. On the other hand, anticancer activity was also performed for the title compounds which demonstrated a significant activity on selected cancer cell lines.