Open AccessNovel Mixed Complexes Derived from Benzoimidazolphenylethanamine and 4-(Benzoimidazol-2-yl)aniline: Synthesis, Characterization, Antibacterial Evaluation and Theoretical Prediction of Toxicity
Author(s) -
Lotfi M. Aroua
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22472
Subject(s) - chemistry , aniline , nuclear chemistry , metal , metal ions in aqueous solution , monoclinic crystal system , antibacterial activity , micrococcus luteus , inorganic chemistry , escherichia coli , organic chemistry , bacteria , crystal structure , biochemistry , biology , gene , genetics
Benzoimidazolphenylethanamine (BPE) has been synthesized using condensation reaction fromo-phenyldiamine and L-phenylalanine. Some metal complexes have been synthesized from4-(benzoimidazol-2-yl)aniline, benzoimidazolylphenylethanamine and cadmium(II), tin(II), copper(II)and nickel(II) metal in a molar ratio (1:1:1). All new metal complexes were characterized byspectroscopic data of FTIR, UV-visible electronic absorption, X-ray powder diffraction and thermalanalysis. Spectra analysis of the mixed metal complexes showed the coordination of ligands to themetal ions via nitrogen atoms. The XRD powder showed that metal complexes have a monoclinicsystem. The preliminary tested in vitro antibacterial activities of Sn(II) complex was assayed againstfour bacterial isolates namely Micrococcus luteus, Staphylococcus aureus as Gram-positive,Pseudomonas aerugmosa and Escherichia coli.