Open AccessNbCl5 and AgClO4 Promoted Regio-Selective Acylation of Indoles
Author(s) -
Narendra R. Kamble,
Hari R. Pawar,
Vinod T. Kamble
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22419
Subject(s) - acylation , chemistry , catalysis , indole test , combinatorial chemistry , organic chemistry
In present study, an efficient and simple strategy towards chemo-selective and regio-selective acylation of indole using NbCl5 and AgClO4 catalyst are reported. This method utilizes the catalytic potentiality of NbCl5 and AgClO4 towards acylation of unprotected indoles in a synergistic manner. The combination of these catalytic system results into numerous advantages such as excellent yields of product, short reaction times and easier isolation of products.