Open Access4-Aminoindane Derived Novel Schiff Base Metal Complexes: Synthesis, Characterization, DNA Binding and Molecular Docking Studies
Author(s) -
S. Arthi,
D. Sumalatha,
K. Susmitha,
Manan Bhargavi,
Alina Jyothi Joseph
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22408
Subject(s) - chemistry , schiff base , ligand (biochemistry) , octahedron , metal , docking (animal) , dna , octahedral molecular geometry , binding constant , stereochemistry , crystallography , binding site , crystal structure , organic chemistry , biochemistry , medicine , receptor , nursing
A novel Schiff base [SAL-L=2-((2,3-dihydro-1H-inden-4-ylimino)methyl phenol] was synthesized and used as ligand for the synthesis of Ni(II) and Co(II) complexes. The structural characterization of ligand and its Ni(II) and Co(II) complexes was determined using various spectroscopic methods. Based on spectral studies, a square planar and octahedral geometry have been proposed for Ni(II) and Co(II) complexes, respectively. DNA binding properties of these metal complexes with calf-thymus DNA in tris-hydrochloride buffer (pH 7.2) were investigated using UV- visible absorption studies. The binding constants were in the order of 105 M-1 suggested a good binding affinity towards CT-DNA.The synthesized ligand is docked on TSPO protein showing good binding energy and found to be a potent inhibitor of cancer.