Open AccessGreen Synthesis of Spiropyranone 3-Aryl-4-Methylcoumarin Derivatives using Carbonyldiimidazole
Author(s) -
Dongamanti Ashok,
E. V. L. Madhuri,
M. Sarasija
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22376
Subject(s) - chemistry , acetophenone , phenylacetic acid , aryl , proton nmr , carbon 13 nmr , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , alkyl
A series of spiropyranone 3-aryl-4-methylcoumarin derivatives have been synthesized frommonospiro-2-hydroxy acetophenone in a novel and efficient green method using imidazolylintermediates and inorganic base. Imidazolyl intermediates were in turn generated by grinding the respective phenylacetic acid along with carbonyldiimidazole (CDI). Similarly, monospiro-2-hydroxy acetophenone derivatives were prepared selectively by avoiding formation of bis derivatives following literature procedure. The titled compounds were purified by preparative TLC technique and were characterized by IR, 1H NMR, 13C NMR as well as mass spectral methods