Open AccessSynthesis, Characterization and Anticancer Activity of Transition Metal Substituted Polyoxometalate-β-Cyclodextrin Composites
Author(s) -
Bharath Samannan,
Jothi Selvam,
Jeyabalan Thavasikani
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22321
Subject(s) - chemistry , a549 cell , apoptosis , cyclodextrin , mtt assay , viability assay , cell culture , electron paramagnetic resonance , composite number , nuclear chemistry , lung cancer , polyoxometalate , ic50 , in vitro , biochemistry , composite material , oncology , nuclear magnetic resonance , materials science , medicine , genetics , physics , biology , catalysis
A novel hybrid composite, namely {[VIV+PMo11O40]⊂[β-CD]} which shows the high percent of apoptosis of MTT assay of A549 cell line (lung cancer) in different concentrations. The composite has been characterized using techniques such as FT-IR, EPR, SEM, EDS and X-ray diffraction. The anticancer (lung cancer A549 cell line) was investigated using direct microscopic observations for drug treated cell line and IC50 value of 1.93. The apoptosis of 45.37 % cell death in cell line of minimum concentration (3.12 μg/mL) shows the good viability of β-CD-POM against lung cancer A549 cellline.