Open Accessβ-Cyclodextrin Mediated Multicomponent Synthesis of Spiroindole Derivatives in Aqueous Medium
Author(s) -
Vishwa Deepak Tripathi
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22311
Subject(s) - chemistry , isatin , aqueous medium , indoline , cyclodextrin , amine gas treating , combinatorial chemistry , quinazoline , aqueous solution , organic chemistry
An efficient β-cyclodextrin catalyzed multicomponent synthetic protocol has been developed for the synthesis of spiro[indoline-3,2'-quinazoline]-2,4'(3’H)-dione from isatoic anhydride, isatin and primary amine in aqueous medium. This methodology offers a convenient method for the synthesis of spiroindole quinazolines in excellent yields. To extend synthetic utility of protocol some dihydro quinazolines have been also synthesized.