Open AccessSynthesis, Characterization and Enzyme Inhibition Activity of Organophosphorus Trichalcones Containing Core-Phosphate Moiety
Author(s) -
Sunil R. Khapate,
D. S. Wankhede,
Anitha S. Deshpande,
Neeta S. Khillare,
Anil Khandagale
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22204
Subject(s) - chemistry , phosphate , moiety , antibacterial activity , enzyme , bacteria , antimicrobial , hydrolysis , bromide , biological activity , enzyme assay , organic chemistry , biochemistry , in vitro , genetics , biology
Facile synthesis of various organophosphorus trichalcones, possessing substantial insecticidal activity, by using tris(4-acetylphenyl)-phosphate (3) and substituted benzaldehydes as a precursor has been reported. Key precursor 3 has been prepared under mild conditions in presence of tetrabutylammonium bromide (TBAB) as a phase transfer catalyst. All the synthesized compounds (5a-h) were screened for their antibacterial activity and inhibition of α-amylase of insect pest, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionadeae). Biological activity evaluation study revealed that among all the compounds screened, compound 5g found to have promising inhibition of α-amylase of insect pest, Tribolium castaneum. All the synthesized compounds revealed insignificant antimicrobial activity against pathogenic bacteria even at 500 μg/mL.