Open AccessCopper Catalyzed Chan-Lam Coupling Reaction of Pyrazoles at Ambient Temperature and their Antimicrobial Evaluation
Author(s) -
Kalpesh V. Vilapara,
Sagar P. Gami,
Shobhna A. Gadara,
Yogesh T. Naliapara
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22370
Subject(s) - chemistry , aspergillus niger , catalysis , yield (engineering) , antimicrobial , antibacterial activity , aryl , nuclear chemistry , carbon 13 nmr , proton nmr , ligand (biochemistry) , coupling reaction , dilution , combinatorial chemistry , organic chemistry , bacteria , food science , biochemistry , biology , materials science , alkyl , metallurgy , genetics , receptor , thermodynamics , physics
An efficient protocol to synthesize a series of N-aryl pyrazoles via C-N bond Chan-Lam coupling reaction using diverse boronic acid at room temperature using Cu(OAc)2/TEA as a catalytic system without utilization of any ligand or additive and exposed to air to afford moderate to excellent yield. The characterizations of newly synthesized compounds were confirmed by FTIR, MS, 1H NMR, 13C NMR, and elemental analysis. All the synthesized compounds were assayed for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, S. typhi MTCC-98, and antifungal activity against Aspergillus niger MTCC-282 and Aspergillus clavatus MTCC-1323 at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.