Open AccessDNA/BSA Binding, Molecular Docking, Nuclease Activity and Cytotoxicity Studies of Hydrazide Based Schiff Base Complexes
Author(s) -
Chinnasamy Muthiah,
A. Ramu
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22308
Subject(s) - chemistry , schiff base , puc19 , hydrazide , binding constant , nuclease , dna , metal , cytotoxicity , metal ions in aqueous solution , stereochemistry , docking (animal) , crystallography , binding site , biochemistry , organic chemistry , in vitro , plasmid , medicine , nursing
A new series of hydrazide based Schiff base metal Cu(II)/Zn(II) complexes of the type [Cu(L1-L4)2] and [Zn(L1-L4)2] has been synthesized and characterized by various analytical and spectral techniques. The proposed geometry of metal complexes, square planar for Cu2+ ion and tetrahedral for Zn2+ ion was confirmed by the spectral and analytical results. DNA interaction with metal complexes was explored by spectral and molecular docking analysis. The results obtained indicates that Cu(II)/Zn(II) complexes interaction with DNA via an intercalative binding mode and its respective intrinsic binding constant (Kb) was found in the order of 7 > 8 > 5 > 6 > 3 > 4 > 1 > 2. Further, similar interactions of these metal complexes with BSA were found in the same order of binding constant. Furthermore, the complexes showed moderate cleavage ability with pUC19 DNA. Cytotoxicity studies confirmed the biological importance of the Schiff base complexes.